2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-RS29474
    Dpm3 Mouse Pre-designed siRNA Set A
    Dpm3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for DPM3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Components
    DPM3 siRNA-1: 5 nmol (HPLC)
    DPM3 siRNA-2: 5 nmol (HPLC)
    DPM3 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Dpm3 Mouse Pre-designed siRNA Set A
  • HY-RS29475
    CEPT1 Human/Cat Pre-designed siRNA Set A
    CEPT1 Human/Cat Pre-designed siRNA Set A contains three designed siRNAs for CEPT1 gene (Human/Cat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Components
    CEPT1 siRNA-1: 5 nmol (HPLC)
    CEPT1 siRNA-2: 5 nmol (HPLC)
    CEPT1 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    CEPT1 Human/Cat Pre-designed siRNA Set A
  • HY-RS29477
    Mmachc Mouse Pre-designed siRNA Set A
    Mmachc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmachc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Mmachc siRNA-1: 5 nmol (HPLC)
    Mmachc siRNA-2: 5 nmol (HPLC)
    Mmachc siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Mmachc Mouse Pre-designed siRNA Set A
  • HY-RS29496
    Prkaa1 Mouse Pre-designed siRNA Set A
    Prkaa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkaa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    Prkaa1 siRNA-1: 5 nmol (HPLC)
    Prkaa1 siRNA-2: 5 nmol (HPLC)
    Prkaa1 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Prkaa1 Mouse Pre-designed siRNA Set A
  • HY-W001146
    3-Chloro-4-hydroxyphenylacetic acid 33697-81-3 98%
    3-Chloro-4-hydroxyphenylacetic acid is a fungal metabolite. 3-Chloro-4-hydroxyphenylacetic acid is an active small molecule, that can be used as building block in synthesis of 17β-HSD2 inhibitors.
    3-Chloro-4-hydroxyphenylacetic acid
  • HY-W011297
    Methyl arachidonate 2566-89-4 99.9%
    Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy.
    Methyl arachidonate
  • HY-W012816
    2-Methylresorcinol 608-25-3 ≥98.0%
    2-Methylresorcinol is a tripyrrane analog. 2-Methylresorcinol is a cosmetic ingredient with endocrine activity. 2-Methylresorcinol combined with Butylhydroxyanisole (HY-B1066) and Avobenzone (HY-B0316) has anti-glucocorticoid-like activity. 2-Methylresorcinol combined with Avobenzone only has anti-androgen-like activity. 2-Methylresorcinol can be used as for cosmetic industry.
    2-Methylresorcinol
  • HY-W013315
    6-Chloropurine-2'-deoxyriboside 4594-45-0 99.42%
    6-Chloropurine-2'-deoxyriboside is a monomeric raw material that can be used for nucleic acid synthesis.
    6-Chloropurine-2'-deoxyriboside
  • HY-W013826
    Carboxytolbutamide 2224-10-4 99.02%
    Carboxytolbutamide is a toluenesulfonamide metabolite.
    Carboxytolbutamide
  • HY-W015467
    Pyridine-3-sulfonic acid 636-73-7 ≥98.0%
    Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid.
    Pyridine-3-sulfonic acid
  • HY-W015966
    3-Methylpyrrole 616-43-3
    3-Methylpyrrole is a pyrrole-type nitrogen-containing heterocyclic aromatic compound. 3-Methylpyrrole can be used as a negative control tool for hexosamine detection.
    3-Methylpyrrole
  • HY-W040221
    Butanoyl PAF 85405-03-4 98%
    Butanoyl PAF, a compound closely related to Azelaoyl PC (HY-134154), maintains over 10% of the agonist potency of platelet-activating factor (PAF). Butanoyl PAF's concentration in oxidized low-density lipoprotein surpasses that of enzymatically generated PAF by more than 100-fold.
    Butanoyl PAF
  • HY-W048518
    7-Deaza-2'-dG 86392-75-8 98%
    7-Deaza-2'-dG (7-Deaza-2'-deoxyguanosine) is a monomeric raw material that can be used for nucleic acid synthesis.
    7-Deaza-2'-dG
  • HY-W073501
    trans-Glutaconic acid 628-48-8 98.92%
    trans-Glutaconic acid (trans-2-Pentenedioic acid) is the trans isomer of Glutaconic acid (HY-W073501A). trans-Glutaconic acid is a neurotoxic metabolite. trans-Glutaconic acid induces weak neurotoxicity in cultured cerebral neocortical neurons. trans-Glutaconic acid elicits significant electrophysiological responses in rat neocortical wedge preparations at high concentrations. trans-Glutaconic acid can be used in studies related to glutaric acidemia type 1.
    trans-Glutaconic acid
  • HY-W078733
    (S)-2-Amino-4,4,4-trifluorobutanoic acid 15960-05-1 ≥98.0%
    (S)-2-Amino-4,4,4-trifluorobutanoic acid ((2S)-2-Amino-4,4,4-trifluorobutanoic acid) is a Sestrin-GATOR2 modulator. (S)-2-Amino-4,4,4-trifluorobutanoic acid can be used in research on diabetes, neurodegenerative diseases, immune diseases, and cancer.
    (S)-2-Amino-4,4,4-trifluorobutanoic acid
  • HY-W089014
    Dimethyl glutarate 1119-40-0 98.84%
    Dimethyl glutarate (Pentanedioic acid dimethyl ester) is an ester product.
    Dimethyl glutarate
  • HY-W097268
    L-Lysinamide dihydrochloride 51127-08-3 99.90%
    L-Lysinamide dihydrochloride is an amide form of L-Lysine (HY-N0469). L-Lysinamide dihydrochloride can be conjugated with Cholesterol (HY-N0322) and L-ornithinamide for use as a DNA delivery agent.
    L-Lysinamide dihydrochloride
  • HY-W098048
    Dimethyl hexadecanedioate 19102-90-0 99.83%
    Dimethyl hexadecanedioate (Hexadecanedioic acid,dimethyl ester) is an ester product.
    Dimethyl hexadecanedioate
  • HY-W099331
    Monoethylglycinexylidide hydrochloride 7729-94-4 98.82%
    Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation.
    Monoethylglycinexylidide hydrochloride
  • HY-W114419
    Bisphenol C 79-97-0 ≥98.0%
    Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC50 values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on.
    Bisphenol C
Cat. No. Product Name / Synonyms Application Reactivity